Peptides  ›  MOTS-c

MOTS-c

Mitochondrial-Derived Peptide · AMPK Activator · Metabolic Reset

Think of MOTS-c as exercise in a vial — it flips your cells into fat-burning, energy-making mode, so you feel leaner and more energized alongside your training.

What it is

MOTS-c is a tiny peptide your own mitochondria make, and it works like a metabolic switch. It flips on AMPK — the same energy sensor that exercise activates — nudging your cells to burn fat for fuel, handle blood sugar better, and build more mitochondria. That's why people call it "exercise in a vial."

Don't expect a jolt: MOTS-c is cumulative. The first week can feel like nothing, then steadier energy and better workout tolerance show up around weeks 2–3, with body-composition changes building over the cycle. Taking it fasted or before training seems to get the most out of it. Honest note — the science is exciting but still mostly from the lab, so treat it as promising rather than proven.

Animal and lab data Studied in animals and in the lab. Consistent results and a good safety record in people who use it, but not the same thing as a human trial.

Your dosing

5 mg · 3× a week (Mon/Wed/Fri)

Most people start straight at 5mg (38 units). If you would rather ease in, run 2.5mg (19 units) first — two, three or four weeks, whichever you want — then step up.

That is 38 units on a U-100 insulin syringe — from a 40 mg vial mixed with 3 ml of water, which gives you 13.33 mg/ml.

Add the water slowly down the inside of the glass and roll it — never shake it. Keep it in the fridge at 2–8 °C once mixed.

Which path fits what you are doing

The same compound, aimed at different things, and they do not all land in the same place. The Protocol Builder will pick one for you if you would rather not choose.

How it actually feels

Injection site stinging is the usual complaint. Some find it too stimulating late in the day.

What helps

• Dose in the morning, fasted or before training
• Keep it away from bedtime
• Rotate injection sites

Usually nothing. It is one of the quieter compounds to be on.

What helps

• Take it in the morning — a few people find it is stimulating enough to notice at night
• Rotate sites

How long you run it

How long: 6 weeks–10 weeks

Break: 4 weeks · max three times a year

What the lab found

Every batch is independently assayed before it is sold, and the lab measures how much peptide is actually in the vial — not just how pure it is. The most recent batch tested here came in 15% over the labelled amount. That is deliberate: we would rather you got more than you paid for than less.